Combining Minoxidil and PRP Injections to Supercharge Hair Growth

Introduction: Hair loss is a common concern affecting millions of people worldwide, with various factors contributing to its occurrence such as genetics, stress and nutritional status. Among the numerous treatments available, the combination of Minoxidil and Platelet Rich Plasma (PRP) injections has gained attention for its powerful synergistic effects in promoting new hair growth and hair maintenance.  This comprehensive guide aims to explore the mechanisms of action behind Minoxidil and PRP, their individual benefits, and the reasons why combining these two treatments may offer superior results in combating hair loss.

Understanding Hair Loss: Before delving into the combined approach of Minoxidil and PRP, it’s essential to understand the underlying causes of hair loss. Genetics, hormonal imbalances, nutritional deficiencies, stress and environmental factors contribute to the disruption of the hair growth cycle, leading to hair thinning and eventual loss. Targeting these factors is crucial for devising effective treatment strategies that promote long term results.

Minoxidil: The Gold Standard Topical Treatment

Minoxidil, a vasodilator initially developed as an antihypertensive medication, gained fame for its unexpected side effect – promoting hair growth. When applied topically, Minoxidil dilates blood vessels, increasing blood flow to the hair follicles. It is thought to extend the anagen (growth) phase of the hair cycle and promote the proliferation of dermal papilla cells, essential for hair follicle health. Additionally, Minoxidil may increase the expression of growth factors and stimulate hair matrix cells, contributing to thicker and longer hair strands.

Despite its efficacy, Minoxidil has limitations. It primarily works on maintaining existing hair and may not fully address the underlying causes of hair loss. This is where complementary therapies, such as PRP injections, come into play.

Platelet-Rich Plasma (PRP): Healing Power of Blood

PRP is a high dose solution of platelets taken from the patient’s own blood, enriched with a high concentration of platelets containing numerous growth factors. These growth factors play a crucial role in tissue repair and regeneration of the hair follicle. When administered via injection into the scalp, PRP aims to stimulate dormant hair follicles, increase blood supply, and promote a favorable environment for hair growth.

The process involves drawing a small amount of the patient’s blood, roughly 100 ml’s, processing it to separate the platelet rich plasma in a centrifuge and then injecting it into the scalp. PRP injections have shown promise in various medical fields, including orthopedics and dermatology, and are increasingly gaining popularity as a non-surgical option for treating hair loss, especially male and female pattern baldness.

Minoxidil and PRP treatment

Why Combine Minoxidil and PRP?

  1. Complementary Mechanisms of Action: Minoxidil and PRP work through distinct mechanisms, making them complementary in addressing different aspects of hair loss. Minoxidil improves blood flow and cell proliferation, while PRP provides a rich source of growth factors that stimulate cellular activity. Combining these treatments may create a synergistic effect, enhancing the overall efficacy in promoting new hair growth.
  2. Addressing Multiple Factors: Hair loss is a multifactorial issue, and a comprehensive approach is often necessary for optimal results because mono therapies generally have limited results. Minoxidil and PRP target various contributing factors, including poor blood circulation, follicle miniaturization, inflammation and cellular dysfunction. By combining these treatments, individuals may benefit from a more comprehensive and holistic approach to hair restoration that outperforms either therapy alone.
  3. Enhancing Nutrient Delivery: Minoxidil, by promoting vasodilation, increases blood flow to the scalp. This enhanced blood circulation can potentially improve the delivery of nutrients and oxygen to the hair follicles. When PRP is introduced, the growth factors it contains may further support nutrient absorption and cellular function, creating an environment conducive to robust hair growth, especially in early to moderate stages of hair loss.
  4. Extended Treatment Durability: Minoxidil is typically a lifelong commitment, and its effects may diminish within 3 months if discontinued. PRP injections, on the other hand, may have longer-lasting effects. Combining these treatments might offer a more sustained solution, potentially reducing the reliance on continuous Minoxidil use while maintaining or even enhancing the achieved results.

Scientific Evidence Supporting the Combination: Numerous studies have explored the efficacy of Minoxidil and PRP individually. However, research specifically focusing on the combined approach is limited but extremely promising. A study published in the International Journal of Trichology in 2022 demonstrated that combining Minoxidil with PRP yielded better results than Minoxidil alone in androgenetic alopecia patients. (1) The study suggested that the synergistic effects of improved blood flow and growth factor stimulation contributed to enhanced hair regrowth.

Another study published in the International Journal of Molecular Science in 2020 investigated the combination therapy in male pattern hair loss vs PRP alone or Minoxidil alone. The results indicated a significant increase in hair density and thickness with the combined Minoxidil and PRP treatment compared to Minoxidil alone or PRP alone mono therapies. (2)

While more research is needed to establish the long-term benefits and optimal treatment protocols, these studies suggest that the combination of Minoxidil and PRP may offer a more effective solution for individuals seeking enhanced hair regrowth.

Clinical Application of Minoxidil and PRP Combination

The combination of Minoxidil and PRP is typically administered in a clinical setting by qualified healthcare professionals, such as Dermatologists, hair restoration specialists or Naturopathic Physicians. The treatment protocol may involve the following steps:

  1. Assessment and Diagnosis: A thorough assessment of the patient’s medical history, scalp condition, and the extent and duration of hair loss is essential for determining the suitability of the combined treatment. Diagnostic tools, such as trichoscopy or scalp biopsies, may aid in identifying the specific type and cause of hair loss.
  2. Minoxidil Application: The treatment often begins with the application of Minoxidil to the affected areas. This topical solution is usually applied once or twice daily, as recommended by the healthcare provider with twice daily being the preferred option. The patient is instructed on proper application techniques to ensure optimal absorption and efficacy.
  3. PRP Extraction and Processing: A small amount of the patient’s blood is drawn, typically 60-100 ml, usually from the arm, and processed in a centrifuge to separate the platelet rich plasma. This concentrated PRP is then collected and prepared for injection by the clinician.
  4. PRP Injections: Using fine needles, typically 30 gauge, the prepared PRP is injected into specific areas of the scalp where hair loss or thinning is prominent. The injections are strategically administered to target the affected follicles and stimulate hair growth. Local anesthesia may be applied to minimize discomfort during the procedure and medications are also advised prior to the start of the treatment.
  5. Follow-up and Maintenance: Patients typically require multiple sessions of combined Minoxidil and PRP treatments to achieve and maintain optimal results. The frequency of sessions may vary based on individual response and the severity of hair loss, but generally are once every 3 months For PRP. Periodic follow-up appointments allow healthcare providers to assess progress and make any necessary adjustments to the treatment plan.  Most patients will apply Minoxidil twice daily on their own and receive 3-4 PRP treatment sessions throughout the year.

Minoxidil and PRP for best hair growth results

Potential Side Effects and Considerations

While Minoxidil and PRP are generally considered safe, it’s crucial to be aware of potential side effects and considerations associated with their combination:

  1. Minoxidil Side Effects: Common side effects of Minoxidil include scalp irritation, itching, and dryness. In rare cases, individuals may experience more severe side effects, such as dizziness or chest pain. It’s important to follow the prescribed dosage and seek medical advice if any adverse reactions occur.
  2. PRP Injection Risks: PRP injections are minimally invasive, but as with any medical procedure, there may be risks. These can include infection, bruising, or localized pain at the injection site. Patients should inform their healthcare provider of any existing medical conditions or medications to ensure a safe and personalized treatment plan.
  3. Individual Response Variability: Responses to combined Minoxidil and PRP treatment can vary among individuals. Factors such as age, genetic predisposition, and the underlying cause of hair loss can influence the outcome. It’s important for patients to have realistic expectations and understand that results may take time to become noticeable.  For most cases results typically aren’t seen until approximately 4 months after the treatments begin.
  4. Cost Considerations: The cost of combined Minoxidil and PRP treatments can vary depending on geographic location, the expertise of the healthcare provider, and the number of sessions required. Patients should discuss the cost implications with their healthcare provider and consider it as an investment in their long-term hair restoration goals.  Generally the cost of daily Minoxidil is very low, approximately $30 a month or less, and PRP costs can be substantially decreased by purchasing multiple treatments bundled in advance.

Conclusion: The combination of Minoxidil and PRP represents a promising approach to addressing the complex and stressful issue of hair loss. By leveraging the vasodilatory and cell-proliferative effects of Minoxidil alongside the regenerative properties of PRP, individuals may experience enhanced and sustained hair regrowth that they can be very satisfied with.

While scientific evidence supporting this combined approach is growing, continued research is needed to refine treatment protocols, establish long-term efficacy, and address individual variability in treatment response. As with any medical intervention, patients should consult with qualified healthcare professionals to determine the most suitable treatment plan based on their unique needs, circumstances and prior medical history.

In conclusion, the synergy between Minoxidil and PRP offers a comprehensive solution that goes beyond mere symptom management, aiming to restore and rejuvenate the intricate processes involved in hair growth. As advancements in hair restoration continue, the combined approach of Minoxidil with PRP injections stands out as a promising strategy for those seeking effective and sustainable solutions to combat hair loss.


1. Elena EP, Irina OS. Combination therapy with platelet-rich plasma and minoxidil leads to better clinical results than monotherapy with these methods in men with androgenetic alopecia. Int J Trichology. 2022;14(1):1-7.
2. Pakhomova EE, Smirnova IO. Comparative evaluation of the clinical efficacy of prp-therapy, minoxidil, and their combination with immunohistochemical study of the dynamics of cell proliferation in the treatment of men with androgenetic alopecia. Int J Mol Sci. 2020;21(18):6516.
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