Stem Cell Signaling Knee Pain Relief | Case Review

Stem cell signaling knee pain relief treatments are now available in Gilbert, AZ and the East Valley communities of Chandler, Queen Creek, San Tan Valley, and Mesa, AZ for patients struggling with chronic joint pain and looking to avoid surgery.

Stem Cell Signaling Knee Pain Relief

Stem Cell Therapy Knee Pain Relief in Gilbert, AZ

Stem cell signaling allografts are a new and exciting treatment option with emerging research indicating potential therapeutic value in orthopedic & sports medicine, family medicine, geriatric medicine, as well as pain management. (1,2,3,4,5,6) The therapy consists of injecting regenerative allografts mixed with growth factors from platelet rich plasma (PRP) into the site of pain or injury. The targeted site begins clearing out the cellular debris and primes the area repair while new cells and growth factors trigger a healing cascade.

Depending on where the stem cell signaling allograft with PRP is injected, they can recruit and modulate the healing process and stimulate connective tissue repair while also lowering down local inflammation.  These unique features support the repair of damaged tissue, with high density platelet rich plasma growth factors enchaining the clinical outcomes. After the completion of the healing cascade, there is localized connective tissue changes to the damaged area allowing potential pain reduction.  Increased functionality of the joint is also observed as structural integrity is strengthened to the joint and surrounding tissue.

Benefits of Regenerative Treatments

  • Pain Relief
  • Quick Recovery Time
  • Non-Surgical / Non-Invasive
  • Affordable and Cost Effective
  • Repairs Ligaments, Tendons, Cartilage, and Connective Tissue
  • Uses your own Natural Growth Factors / Cells

Stem Cell Signaling Knee Pain: A Case Study

Naturopathic Stem Cell Therapy Knee Pain injections in Gilbert, AZ

Marty Nelson (fictional name) is 71 year old male presenting to my Gilbert, AZ clinic with knee pain of 9 years duration.  Marty has lived a very active lifestyle his entire life but knee pain has greatly reduced his current activities.  He reports that the pain began very slowly and he could power through it initially.  After a couple of years, the pain continued to increase and he went in to his primary care doctor.  The doctor ordered imaging and and diagnosed Marty with osteoarthritis of both knees.  Marty began taking Ibuprofen to reduce his knee pain and continued his activities.  Eventually, this had no effect on his knee pain and he begin getting injections of Synvisc (hyaluronic acid).  For the past 6 years Marty has been getting Synvisc injections in his knees, that have provided pain relief but have diminished over time.  

I examined Marty’s history, completed orthopedic physical exams on his knees and ordered a new MRI.  The imaging report indicated continued degeneration that was worse on his medial knees with a minor meniscus tear in his right knee.

My assessment was:

  • Knee Osteoarthritis Bilaterally
  • Pain 6/10
  • Exercise Intolerance
  • Impaired Daily Living Activities
  • Decreased Range of Motion Bilaterally

After a complete assessment and review of Marty’s case history, I decided he was a good candidate for a regenerative allograft with PRP treatment.  Due to the severity of his osteoarthritis, I projected that he may need 1 allograft treatment and 2 PRP follow-up treatments over a period of 12 weeks.  We started with the signaling allograft with PRP treatment in both of his knees.  Marty tolerated the treatment fairly well, but did have some tenderness on his medial knees.  He reported pain relief right away, most likely due to increased fluid in the knee joint.  We then proceeded to complete the recommended PRP follow-up appointments.  At the 12 week mark, I checked up with Marty and found his pain had decreased to 0/10 resting and would only go up to 1/10 if he was very active all day long.  Marty was thrilled with the improvements that were achieved and was excited to resume hiking and woodworking activities at home.


Stem Cell Therapy Knee Pain injections in Gilbert, AZ
Knee Pain

Stem cell signaling knee pain injections are an effective option for knee pain (osteoarthritis) and has anecdotally proven to me more effective than conservative care and hyaluronic acid injections from our clinical observations.  Marty had been experiencing knee pain for 9 years and a replacement surgery was the next option after his Synvisc injections had stopped working.  Regenerative allograft injections with PRP help the knee joint repair and treat the root cause of degenerative arthritic pain.  Cartilage, tendons, and ligaments are strengthened, which reduces pain and increases range of motion of the knee joint.  Stem cell signaling allografts should be considered as a new alternative to knee replacement surgery, opioid medications, hyaluronic acid and cortisone injections.  From my clinical experiences, regenerative injections (allografts, ECM, PRP) are very effective and will definitely play a huge role in the evolution of pain management and orthopedic sports medicine.  For more information about Regenerative Injection Therapy, autologous stem cell provider referrals, Platelet Rich Plasma, integrative pain management, or our Gilbert, AZ location, please contact us at: 480-648-1534

Free, 15-Minute Consultation

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Additional Resources








Complementary Knee Pain Guide

How to Eliminate Knee Pain and Enjoy a Healthy Active Lifestyle Again, without Surgery

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Facebook Knee Pain Support Group


Dylan Krueger, NMD


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