Overview of PRP
Platelet Rich Plasma or PRP is a cutting-edge new therapy that helps regenerate damaged connective tissue such as cartilage, tendons, and ligaments for pain relief. The treatment has gained great popularity after professional athletes such as Steph Curry, Kobe Bryant, Peyton Manning and many more have successfully had the procedure done. The treatment involves taking blood from the patient, centrifuging it, extracting the PRP growth factor content, and then injecting the cells back into the area of pain and injury. The treatment is straightforward and effective with minimal downtime.
Benefits of Platelet Rich Plasma
- Pain Relief
- Quick Recovery Time
- Non-Surgical / Non-Invasive
- Regenerates your own connective tissue
- Utilizes your Natural Growth Factors / Cells
- Cost-Effective
PRP Growth Factor Functions
Platelet Derived Growth Factor
Cellular growth, neutrophil recruitment and other cellular recruitment to the site of injury or connective tissue damage, collagen production, blood vessel repair and regeneration, connective tissue regeneration, increases regeneration in smooth muscle cells/glial cells/fibroblasts, angiogenesis and macrophage activation.
Transforming Growth Factor
Control of endothelial, osteoblastic, fibroblastic cell movement and new vessel formation, collagenase secretion, promotion of other growth factors, increase fibroblast and osteoblast growth, promotion of connective tissue healing, bone matrix formation, growth of epithelial cells, stimulation and growth of stem cells.
Insulin-Like Growth Factor
Bone matrix formation, increases cartilage growth, wound healing, growth of osteoprogenitor cells, encourages cellular replication of osteoblasts, fibroblasts and endothelial cells.
Vascular Endothelial Growth Factor
Promotes new blood vessels and increased capillary function and expression increased in presence of minimal oxygen.
Epithelial cell growth, new blood vessel formation, promotion of wound healing, induction of membrane formation, keratinocyte recruitment and granulation tissue formation.
Fibroblast Growth Factor
Cell growth, tissue repair, collagen production, hyaluronic acid production.
Connective Tissue Growth Factor
Increased wound healing, new blood vessel formation, cartilage growth, bone growth, and tissue repair fibrosis.
Platelet Derived Angiogenesis Growth Factor
New blood vessel formation, increased capillary function and flow, and stimulation of endothelial cell growth.
Keratinocyte Growth Factor
Proliferation, differentiation and regeneration of keratinocytes.
Interleukin-8
Induction of movement and recruitment in target cells, stimulate their migration toward site of infection, pro-inflammatory, and recruiting fibroblasts and endothelial cells.
Platelet Factor-4
Movement and recruitment of neutrophils and fibroblasts.
Platelet-Derived Epidermal Growth Factor
Recruiter of monocytes, neutrophils and fibroblast cells. It stimulates extracellular matrix formation. Promotes proliferation, blood vessel formation, migration of connective tissue cells.
Stimulates cell proliferation, differentiation, killing of damaged cells, lipid metabolism, and coagulation.
Mediates the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and cellular death of damaged cells.
Interleukin-8
Induces movement in target cells, stimulate their migration toward site of injury, pro-inflammatory, recruiting fibroblasts and endothelial cells.
Summary of PRP Growth Factor
Platelet Rich Plasma contains many very different and specific growth factors that all contribute to connective tissue healing, regeneration, and pain relief. This is achieved through a variety of biological processes with many different cells working locally to ultimately regenerate new tissue. PRP is a cutting-edge new procedure that has emerged out of orthopedic and sports medicine and is now widely available in pain management. The treatment uses your own cells and growth factors and delivers safe and effective pain relief for a variety of musculoskeletal conditions.
